Does Rejuran Actually Work for Dark Circles and Under-Eye Hollowness?

Written By MK Nguyen
 

What Is Rejuran?

Rejuran is an injectable skin booster made from salmon-derived polynucleotides (PDRN). It’s designed to stimulate fibroblasts, increase collagen and skin elastin, enhancing hydration and microcirculation. It also helps reduce inflammation, a key factor in rejuvenating and strengthening the delicate skin around the eyes.

What is periorbital aging and causes periorbital aging?

Periorbital aging also known as under eyes refers to the visible signs of aging around the eyes specifically the area known as the periorbital region, which includes the eyelids, under-eye area, and the skin surrounding the eyes.

Dark circles and undereye hollows stem from multiple causes:

  • Volume loss (fat and tissue breakdown) casting shadows and emphasizing hollows.

  • Thin, lax skin, making blood vessels visible and highlighting discoloration.

  • Pigmentation (genetic or UV-induced).

  • Poor circulation, allergies, or lifestyle factors exacerbating bluish or puffy under‑eyes.

How Rejuran Addresses Dark Circles & Hollows

Thin skin and visible vessels: Rejuran stimulates collagen and elastin synthesis through fibroblast activation, resulting in thicker, firmer under-eye skin that helps reduce shadowing and the visibility of blood vessels.

Shadow from hollows: By increasing hydration, dermal volume, and structural support, Rejuran makes under-eye hollows appear less deep and more naturally plumped.

Pigmentation and poor microcirculation: Rejuran enhances VEGF-mediated microcirculation and accelerates cellular repair, which helps reduce bluish discoloration and dullness around the eyes.

Rejuran Treatment Protocol

  • Sessions: Typically 3 sessions, 4 weeks apart

  • Maintenance: Results can last 9-12 months; annual top-ups recommended

  • Onset: Progressive benefits initial hydration in weeks; structural improvements (thickness, elasticity) by ~12 weeks

  • Safety: Fine needles, minor redness/bruising; polynucleotides are well-tolerated with low risk of allergenicity

Rejuran vs Other Treatments for Under Eye Hollowing

  • Versus Hyaluronic Acid Fillers: Fillers offer instant volume but don’t regenerate tissue. Rejuran builds skin quality thicker, stronger, more rejuvenated

  • Versus Platelet-Rich Plasma (PRP): PRP boosts growth factors from your own blood; Rejuran delivers concentrated polynucleotides, offering complementary regenerative effects.

  • Part of a multi-modal regimen: Best results often come from combining Rejuran with topicals (retinoids, antioxidants, SPF) and other in‑clinic therapies (microneedling, lasers, PRP).

Rejuran Ideal Candidates

  • Those with thin, lax under‑eye skin, visible discoloration, or early hollowness.

  • Individuals seeking natural rejuvenation without foreign fillers, and willing to commit to multiple sessions.

  • Not ideal for clients requiring immediate volume correction for rapid dramatic changes, hyaluronic acid fillers may be more appropriate.

Final Thoughts

Rejuran can work for dark circles, but the results depend heavily on the underlying cause. It is most effective for improving skin quality and subtle brightness. It is not a replacement for fillers or lasers if structural issues or pigmentation are the main problem.

A skilled doctor/nurse will not only tailor the treatment to your facial features but also help determine the ideal timeline for your next check up or touch up based on how your body responds. This personalised approach ensures you maintain a balanced and natural look over time.

To learn more or to book a consultation with a qualified expert, book TT Aesthetics.

MK Nguyen