Understanding Adverse Reactions to Rejuran: When to Seek Help

Rejuran is a polynucleotide-based injectable treatment designed to support skin repair, hydration, and regeneration. It is often used in delicate areas such as under the eyes, where it may help improve texture and fine lines. While generally well tolerated, Rejuran, like all injectable treatments, carries some risk of adverse reaction. Knowing what to expect and recognising warning signs early is essential for anyone considering or currently receiving this treatment.

What Is a Normal Response to Rejuran?

Following Rejuran treatment, some mild and temporary side effects are expected. These typically include:

  • Small raised bumps at the injection sites (commonly called "blebs")

  • Mild redness, swelling or sensitivity

  • Localised tenderness

  • Occasional light bruising

These effects usually resolve within a few days. Your practitioner will advise you on typical timelines based on the treatment area and your skin type.

When Reactions May Indicate a Problem

While uncommon, some patients may experience responses that go beyond the normal recovery process. These may include:

  • Persistent or increasing swelling beyond a few days

  • Redness, heat or pain that worsens over time

  • Itching, rash or hives near the injection site

  • Puffiness or tightness that interferes with vision (especially around the eyes)

  • Delayed flare-ups weeks after treatment

  • Any visual disturbance, severe discomfort or signs of infection

If any of these symptoms occur, it is important to contact your clinic promptly for a medical review.

Why Do Adverse Reactions Happen?

Adverse responses to Rejuran may be influenced by:

  • Skin sensitivity or underlying inflammatory conditions

  • Incorrect technique or placement too close to sensitive structures

  • Product-related sensitivity

  • Pre-existing allergies or autoimmune history

It is critical that all patients undergo a full medical consultation prior to treatment to assess suitability and risk factors.

The Role of Ongoing Clinical Support

At TT Aesthetics, patient safety and care do not end after the treatment session. We provide detailed aftercare guidance and remain available to support you if anything feels unusual. Timely assessment ensures peace of mind and prevents complications.

How Patients Can Stay Informed and Safe

  • Always attend a pre-treatment consultation with a qualified practitioner

  • Share your full medical history, including past reactions and allergies

  • Follow all aftercare advice closely

  • Monitor your skin in the days and weeks following treatment

  • Seek help promptly if you notice unusual symptoms

Being informed about what to expect and understanding when to seek medical input is a key part of a responsible Rejuran journey.

This content is intended for educational purposes and does not constitute medical advice or a recommendation for treatment. Only licensed healthcare providers should perform injectable procedures.

To learn more or to book a consultation with a qualified expert, book TT Aesthetics.

Learn more about Rejuran
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Rejuran Around the Eyes: Benefits, Risks and When to Avoid It

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What to Expect During a Rejuran Treatment